Restylane® and Perlane® Injectable Gels
How does Restylane work?
Restylane adds volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds).
Restylane works immediately by adding volume to smooth away wrinkles. A clear gel formulation of hyaluronic acid, Restylane is specifically formulated to act like your body’s own hyaluronic acid. So, you can use Restylane to visibly reduce moderate to severe facial wrinkles and folds for a younger-looking you.
Biocompatible with the human body, Restylane is eventually broken down naturally.
How does Perlane work?
Just like Restylane, Perlane adds volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds).
Like Restylane, Perlane is a clear gel formulation of hyaluronic acid that is specifically formulated to add fullness like your body’s own hyaluronic acid.
What makes Perlane different is the average size of the particles and the depth of injection. On average, the gel particles in Perlane are larger than those in Restylane, which makes Perlane a good choice for wrinkles that benefit from a deeper injection into the skin.
In three clinical studies of 150 patients each, on average 70% of patients maintained improvement for six months after just one Perlane treatment.
During your consultation, your healthcare professional will decide which product is right for you.
Get a more comfortable lift with Restylane-L and Perlane-L*
If you want a more youthful appearance, but you’re concerned about the potential discomfort from treatment, you can get beautiful results and a more comfortable treatment experience with Restylane-L or Perlane-L.
By combining lidocaine with Restylane® and Perlane®, Restylane-L and Perlane-L help reduce discomfort during and after treatment.
In clinical studies evaluating the Restylane family of products:
- 72% of patients reported significantly less pain during treatment with Restylane-L vs. Restylane.
- 95% of patients reported significantly less pain during treatment with Perlane-L vs. Perlane.
- Patients continued to experience less discomfort for up to one hour after treatment.
*When compared to Restylane and Perlane, respectively.
Where can the Restylane® family of products be used?
The Restylane family can be used to add volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds or laugh lines).
The Restylane family can also be used in other moderate to severe facial wrinkles such as lipstick lines—the area just below the nose and above the upper lip; the corners of the mouth; and marionette lines—the area that extends downward from the corners of the mouth to the jawline.
The safety and effectiveness of products in the Restylane family for the treatment of anatomic regions other than nasolabial folds have not been established in controlled clinical studies. Patients should be limited to 6.0 mL per treatment.
History and safety
Restylane® injectable gel is the world’s most studied wrinkle filler with more than a decade of use. Products in the Restylane family have well-defined safety profiles and are approved for the treatment of moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds).
Restylane and Restylane-L® are indicated for mid-to-deep dermal implantation. Perlane® and Perlane-L® are indicated for implantation into the deep dermis to superficial subcutis.
Restylane is the #1-selling wrinkle filler in the world and has been used in more than 10 million treatments in more than 65 countries worldwide. *
The Restylane family of products are made of a clear gel formulation of hyaluronic acid. Biocompatible with the human body, these products are eventually broken down naturally.
After your treatment, you might have some swelling, redness, pain, bruising, or tenderness. This will normally last less than seven days.
The Restylane family of products should not be used by people with previous bad allergies, particularly to certain microorganisms known as gram-positive bacteria; by people with previous bad allergies to drugs who have required in-hospital treatment; or by people with bleeding disorders. Injections should not be made anywhere except the skin or just under the skin. Restylane-L and Perlane-L should not be used by people with a known allergy to lidocaine.
To avoid bruising and bleeding, you should not use any products in the Restylane family if you have recently used drugs that thin your blood or prevent clotting.
*Includes Q-Med AB HA products not available in the United States.
How long does treatment last?
The Restylane® family of products instantly adds volume to help restore youthful contours, so you’ll see results immediately following your treatment. There is little to no downtime.
In a clinical study of laugh lines (nasolabial folds), at least 95% of patients treated with Restylane continued to see results for up to 18 months after initial treatment when patients returned for a follow-up treatment at 4.5 or nine months. To learn how to get beautiful, long-lasting results with the Restylane Regimen, click here.
In three clinical studies of 150 patients each, on average 70% of patients maintained improvement for six months after just one Perlane treatment.
